Blood going to portions of the lung which are inadequately ventilated will be starved of oxygen. Ventilation-perfusion mismatch (V-Q mismatch): Some parts of the lung have excess ventilation, whereas other parts have inadequate ventilation.This generally occurs in one of two ways: Hypoxemia occurs when blood somehow passes from the right ventricle into the left ventricle without being fully oxygenated. These problems typically run together, but under certain situations they can become divorced. The key to understanding this is thinking about oxygenation and CO2 clearance separately. understanding the paradox of happy hypoxemia However, COVID is causing us to re-think how to manage this physiology. This isn’t anything especially new – we have occasionally seen this since time immemorial.
Happy hypoxemia is severe hypoxemia (poorly responsive to supplemental oxygen) without dyspnea.
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